The Stereoisomer Generator Plugin is able to enumerate all possible stereoisomers of a given compound. The plugin can handle both tetrahedral- and double-bond-type stereo centers.
Fig. 1 Generated stereoisomers shown in MarvinView
Importing generated isomers
To replace your original input molecule in the sketcher with any of the isomers generated first click on the isomer. Then press "Select" at the bottom of the result window (The result window will be closed after pressing "Select").
Fig. 2 Generated stereoisomers shown in MarvinSpace
On filtering invalid structures
If "Filter invalid 3D structures" option is switched on in the Stereoisomers Options panel, stereoisomers can also be displayed in 3D.
The panel of the plugin has the following options to set:
Tetrahedral stereo isomers: only the R/S isomers are generated.
double bond stereo isomers: only E/Z isomers are generated.
both: both R/S and E/Z isomers are generated.
Generate all stereoisomers: all isomers are generated
Generate maximum: sets an upper limit for the number of generated isomers. This option gets enabled if not all isomers are generated.
Protect tetrahedral stereo centers: if checked, stereocenters already pre-set are not included in the stereoisomer generation.
Protect double bond stereo: if checked, all double bonds with pre-set stereo information remain intact.
Filter invalid 3D structures: sterically restricted isomers are discarded.
Display in 3D: results are displayed in a 3D viewer. By default the results are shown in a 2D panel, one for each generated isomer. This option is enabled only if 3D filtering is enabled.
Fig. 3 Options window for stereoisomer calculation
Stereoisomer Generator demo page
You can try our Stereoisomer Generator for free on this demo page.
Smith, M. B.; March, J. Advanced Organic Chemistry, 5th ed., Wiley Interscience, New York, 2001; pp 1218-1223. ISBN 0471585890