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Markush Web Services provide enumeration of Markush structures.

Markush Web Services application is available in two modes:

  1. As part of a microservices system
  2. As standalone web application

Microservices system mode

In microservices system mode the Markush Web Service runs together with Config service, Discovery service and Gateway service. These three services are mandatory and optionally other services can also be part of the system. All configuration must be done in the Config module.

The default configuration applies to the microservices system mode.

The web application runs on host <server-host> and listens on port <gateway-server-port>.

Standalone web application mode

In standalone web application mode the Markush Web Service runs alone, without the Config service, Discovery service and Gateway service (however the installer installs them, as well).

The default configuration must be changed according to the standalone web application mode; set eureka.client.enabled=false in file and in file.

All configuration must be done in the Markush Web Services module.

The web application runs on host <server-host> and listens on port <server-port>.


See here.

Software requirements

See here


See here.

Module is installed into folder: jws/jws-markush


See here.


See here.


Default configuration:



set eureka.client.enabled=false to switch to standalone Markush Web Services application mode${CONFIG_SERVER_URI:http\://localhost\:8888/}

For more settings possibilities see spring documentation page.

Running the server

Prerequisites in case of microservices system mode:

  1. Config service is running
  2. Discovery service is running
  3. Gateway service is running

Run the service in command line in folder jws/jws-markush:

jws-markush-service start (on Windows)

jws-markush-service start (on Linux)


run-jws-markush.exe (on Windows)

run-jws-markush (on Linux)

API documentation

Find and try out the API on the Swagger UI.

ModeURL of Swagger UIDefault URL of Swagger UI
Microservices system<serverhost>:<gateway-port>/jws-markush/API/localhost:8080/jws-markush/API/
Standalone web application mode <serverhost>:<server-port>/API/localhost:8065/API/

Demo site

For detailed description check out the JWS Markush demo site:


Follow the guidelines, examples on the Demo site or on the Swagger UI API documentation of your installed module.

Markush Web Service provides a method for Markush enumeration of chemical structures.

For input structures plain text chemical file formats are supported.

The format of the output structures is MRV.