Relative configuration of tetrahedral stereo centers

In the case of stereogenic centers absolute and relative stereo configurations are both supported. Both the MDL stereo representations (chiral flag and enhanced stereo representation) and the Daylight stereo representation are supported. All molecules originating from Daylight SMILES represent absolute stereo configuration, as SMILES does not support relative configuration.

MDL Enhanced Stereo Representation

In MDL's enhanced stereo representation all stereo center atoms are labeled with one of the following:

  1. ABS

  2. ORn

  3. ANDn

They define a grouping of the stereogenic centers.

Stereogenic centers belonging to ABS represent absolute stereochemistry, i.e. chirality. (All unlabeled stereo centers are also thought to belong to the ABS group by default.)

Stereogenic centers belonging to an ORn group (e.g. OR1) represents one stereoisomer that is either the structure as drawn (R, S) OR the epimer in which the stereogenic centers have the opposite configuration (S, R).

Stereogenic centers belonging to an ANDn group (e.g. AND1) represents a mixture of two enantiomers: the structure as drawn AND the epimer in which the stereogenic centers have the opposite configuration. (e.g. racemic mixture.)

For example:

Molecule

Interpretation

images/download/attachments/1806291/rel_conf_of_tet_ster_cent_3.gif

A pure sample of one stereoisomer:

images/download/attachments/1806291/rel_conf_of_tet_ster_cent_3.gif

images/download/attachments/1806291/rel_conf_of_tet_ster_cent_2.gif

A pure sample of one of these enantiomers:

images/download/attachments/1806291/rel_conf_of_tet_ster_cent_30.gif orimages/download/attachments/1806291/rel_conf_of_tet_ster_cent_4.gif

images/download/attachments/1806291/rel_conf_of_tet_ster_cent_5.gif

A pure sample of one of these enantiomers:

images/download/attachments/1806291/rel_conf_of_tet_ster_cent_6.gif orimages/download/attachments/1806291/rel_conf_of_tet_ster_cent_7.gif

images/download/attachments/1806291/rel_conf_of_tet_ster_cent_8.gif

A sample that is a mixture of the two enantiomers:

images/download/attachments/1806291/rel_conf_of_tet_ster_cent_30.gif andimages/download/attachments/1806291/rel_conf_of_tet_ster_cent_4.gif

images/download/attachments/1806291/rel_conf_of_tet_ster_cent_10.gif

A pure sample of one of these diastereomers:

images/download/attachments/1806291/rel_conf_of_tet_ster_cent_30.gif orimages/download/attachments/1806291/rel_conf_of_tet_ster_cent_4.gif or

images/download/attachments/1806291/rel_conf_of_tet_ster_cent_7.gif orimages/download/attachments/1806291/rel_conf_of_tet_ster_cent_6.gif