| Keyboard shortcut | Function | 
|---|---|
| Esc | Closes the dialog boxes; Activates the Selection tool if there is no selection on the canvas (The default selection tool will be the active tool) | 
| Del | Deletes any selection on the canvas, and deletes an atom or bond for hover-over without selection, too | 
| Ctrl+Del | Clears the canvas | 
| Ctrl+O | Opens the Import dialog | 
| Ctrl+S | Opens the Export dialog | 
| Ctrl+Z | Performs undo action | 
| Ctrl+Y | Performs redo action | 
| Ctrl+A | Select all | 
| Ctrl+X | Cut | 
| Ctrl+C | Copy | 
| Ctrl+V | Paste | 
| Enter | Zoom All | 
| Ctrl + Enter | Zoom to selection | 
| Ctrl + D | Activates the Drawing tool | 
| Keyboard shortcut | Function | 
|---|---|
| D | Places the deuterium atom symbol on the cursor. | 
| T | Places the tritium atom symbol on the cursor. | 
| R+Space | Opens the R-group dialog. | 
| . | Opens the Atom query properties dialog. | 
| Space | Opens the Abbreviated groups dialog. | 
| Alt+1-9 | Places atom map labels 1-9 | 
| Keyboard Shortcut | Bond type | 
|---|---|
| Ctrl+D | Drawing | 
| 1 | Single bond | 
| 2 | Double bond | 
| 3 | Triple bond | 
| 4 | Aromatic bond | 
| 5 | Single Up wedge bond | 
| 6 | Single Down wedge bond | 
| 7 | Single Up or Down query bond | 
| - | Double Cis or Trans query bond | 
| - | Double C/T or Unspecified query bond | 
| 12 | Single or Double query bond | 
| 14 | Single or Aromatic query bond | 
| 24 | Double or Aromatic query bond | 
| 0 | Any query bond | 
| - | Coordinate bond | 
| Context of usage | Function | 
|---|---|
| During 3D rotation with dragging the mouse cursor | Sets the rotation to the horizontal and vertical axis. | 
| Atom or abbreviation drawing | Sprouting from an atom. | 
| During merging template to an atom or bond | Before releasing the left mouse button, pressing Shift button repeatedly rotates the template to the right orientation. | 
| Selection | More than one unconnected structural parts can be selected simultaneously. | 
| Bond drawing by bond tool | Changes the direction of the newly formed bond. | 
| Drawing tool | The drawing points are forming a pentagon instead of hexagon. | 
| Rotating | Sequential rotation instead of incremental. | 
| Moving the rotation center | Prevents the center from snapping to its original place, if the new center is too close to the original. | 
| Abbreviated group drawing | Expands the abbreviated group before merging to the canvas. |